Dexketoprofen trometamol loaded solid lipid nanoparticles (SLNs): Formulation, in vitro and in vivo evaluation
نویسندگان
چکیده
منابع مشابه
Zaltoprofen Loaded Solid Lipid Nanoparticles for Topical Delivery: Formulation Design, In Vitro and Ex Vivo Evaluation
The number of new pharmaceutical compounds with poor aqueous solubility has grown steadily over the last two decades due to the progress in discovery technologies, e.g. high throughput and combinatorial screening tools, during lead development and optimization phase. Most of these compounds are mainly categorized as bio pharmaceutics classification system (BCS) class II for which their oral abs...
متن کاملDevelopment of Topical Gel of Capsaicin Loaded Solid Lipid Nanoparticles (SLNs): in vitro and in vivo Evaluation
Purpose: The aim of this study was to evaluate and compare the in vitro and in vivo topical potential of solid lipid nanoparticles (SLNs) gel for capsaicin. Methods: SLNs were prepared by high shear homogenization and ultrasonication using capsaicin. Then SLNs gel was formulated by hydration method using carbopol 940. Results: The mean particle size, width of distribution, zeta potential and en...
متن کاملFormulation and ex vivo Evaluation of Solid Lipid Nanoparticles (SLNS) Based Hydrogel for Intranasal Drug Delivery
Risperidone (RISP) is an antipsychotic agent and has low water solubility and nontargeted delivery results in numerous side effects. Hence, an attempt was made to develop SLNs hydrogel for intranasal delivery of RISP to achieve maximum bioavailability and reduction of side effects. RISP loaded SLNs composed of 1.65% (w/v) lipid mass were produced by high shear homogenization (HSH) coupled ultra...
متن کاملFormulation , characterization and In Vitro - In Vivo evaluation of Ketorolac - loaded Solid lipid nanoparticles for transdermal delivery
The present study was aimed at developing aqueous dispersion of Ketorolac-loaded solid lipid nanoparticles (SLN) by high speed stirring followed by ultrasonication technique and then incorporation into freshly prepared gel for transdermal delivery. A statistical central composite design was applied to study the effect of drug/lipid ratio and soya lecithin concentration on particle size and entr...
متن کاملFormulation & Evaluation of Gemcitabine Hydrochloride Loaded Solid Lipid Nanoparticles
INTRODUCTION Gemcitabine hydrochloride is an antimetabolite (pyrimidine analog) with poor oral bioavailability (9%) due to the first pass metabolism. GEM is a water soluble drug (log p = -1.4) with a short half-life of 42 to 94 minutes (short infusions) and 245 to 638 minutes (long infusions) respectively. Extensive first pass metabolism, low bioavailability, high dosing frequency and less half...
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ژورنال
عنوان ژورنال: Journal of Research in Pharmacy
سال: 2020
ISSN: 2630-6344
DOI: 10.35333/jrp.2020.114